Plasma nitrate, dietary nitrate, blood pressure, and vascular health biomarkers: a GRADE-Assessed systematic review and dose-response meta-analysis of randomized controlled trials
EvidenceBased paper brief · PMID 40128734
Mostafa Norouzzadeh et al. · Nutr J
Study publication year: 2025. Retrieved: 2026-10-16T22:16:36.333Z.
https://evidencebased.info/studies/40128734
https://pubmed.ncbi.nlm.nih.gov/40128734/
This is a dated public record snapshot. Check the canonical study page for later publication, withdrawal or review changes. It is not a recommendation or human clinical review.
Quick takeaway
Authors reported WMD 32.7 µmol/L; 95% CI 26.1 to 39.4.
Systematic review / meta-analysis: 75 RCTs, 1823 participants. Per 1 mmol increase in dietary nitrate. Source window: acute.
Authors reported WMD 19.6 µmol/L; 95% CI 9.95 to 29.3.
Systematic review / meta-analysis: 75 RCTs, 1823 participants. Per 1 mmol increase in dietary nitrate. Source window: chronic-term.
Authors reported WMD -0.28 mmHg; 95% CI -0.4 to -0.17.
Systematic review / meta-analysis: 75 RCTs, 1823 participants. Per 1 mmol increase in dietary nitrate. Source window: acute.
Authors reported WMD -0.24 mmHg; 95% CI -0.4 to -0.07.
Systematic review / meta-analysis: 75 RCTs, 1823 participants. Per 1 mmol increase in dietary nitrate. Source window: short-term.
Authors reported WMD -0.48 mmHg; 95% CI -0.71 to -0.25.
Systematic review / meta-analysis: 75 RCTs, 1823 participants. Per 1 mmol increase in dietary nitrate. Source window: medium-term.
Authors reported WMD -0.12 mmHg; 95% CI -0.21 to -0.03.
Systematic review / meta-analysis: 75 RCTs, 1823 participants. Per 1 mmol increase in dietary nitrate. Source window: not specified.
Authors reported WMD -0.07 m/s; 95% CI -0.11 to -0.03.
Systematic review / meta-analysis: 75 RCTs, 1823 participants. Per 1 mmol increase in dietary nitrate. Source window: medium-term.
Authors reported WMD 0.3 %; 95% CI 0.15 to 0.46.
Systematic review / meta-analysis: 75 RCTs, 1823 participants. Per 1 mmol increase in dietary nitrate. Source window: medium-term.
Authors reported WMD -0.57 %; 95% CI -0.98 to -0.15.
Systematic review / meta-analysis: 75 RCTs, 1823 participants. Per 1 mmol increase in dietary nitrate. Source window: medium-term.
What this paper studied
These records restate the authors’ findings with their own comparisons, source windows and uncertainty. They are pending human review and are not a platform synthesis or recommendation.
- AI-extracted — pending human review
- Source status is not human clinical review.
- Authors-reported records; platform synthesis is not enabled.
- What the paper set out to compare
- Not available in this record
- Who was studied
- Systematic review / meta-analysis: 75 RCTs, 1823 participants. Per 1 mmol increase in dietary nitrate. Source window: acute.
- How it was designed
- Systematic review / meta-analysis
- Studied intervention
- Not available in this record
- Compared against
- Not available in this record
- What was measured, and when
- plasma nitrate
- What the authors reported
- Authors reported WMD 32.7 µmol/L; 95% CI 26.1 to 39.4.
Fields marked not available are not encoded in this source record and have not been inferred.
Study limitations and interpretation bounds
- Authors-reported systematic-review estimate; no platform synthesis.
plasma nitrate
- AI-extracted — pending human review
- Source-authored record; platform synthesis is not enabled for this record.
- Publication status: published.
Exact source-reported results
Each record retains its source-reported context and uncertainty.
Studied context
- Authors-reported finding
- Authors reported WMD 32.7 µmol/L; 95% CI 26.1 to 39.4.
Limitations
- Authors-reported systematic-review estimate; no platform synthesis.
Sources and exact versions
- Stable finding ID
- finding:examine2025:40128734:1
- Source document version
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- Finding revision
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- Finding version
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- Finding content hash
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plasma nitrate
- AI-extracted — pending human review
- Source-authored record; platform synthesis is not enabled for this record.
- Publication status: published.
Exact source-reported results
Each record retains its source-reported context and uncertainty.
Studied context
- Authors-reported finding
- Authors reported WMD 19.6 µmol/L; 95% CI 9.95 to 29.3.
Limitations
- Authors-reported systematic-review estimate; no platform synthesis.
Sources and exact versions
- Stable finding ID
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systolic blood pressure
- AI-extracted — pending human review
- Source-authored record; platform synthesis is not enabled for this record.
- Publication status: published.
Exact source-reported results
Each record retains its source-reported context and uncertainty.
Studied context
- Authors-reported finding
- Authors reported WMD -0.28 mmHg; 95% CI -0.4 to -0.17.
Limitations
- Authors-reported systematic-review estimate; no platform synthesis.
Sources and exact versions
- Stable finding ID
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systolic blood pressure
- AI-extracted — pending human review
- Source-authored record; platform synthesis is not enabled for this record.
- Publication status: published.
Exact source-reported results
Each record retains its source-reported context and uncertainty.
Studied context
- Authors-reported finding
- Authors reported WMD -0.24 mmHg; 95% CI -0.4 to -0.07.
Limitations
- Authors-reported systematic-review estimate; no platform synthesis.
Sources and exact versions
- Stable finding ID
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systolic blood pressure
- AI-extracted — pending human review
- Source-authored record; platform synthesis is not enabled for this record.
- Publication status: published.
Exact source-reported results
Each record retains its source-reported context and uncertainty.
Studied context
- Authors-reported finding
- Authors reported WMD -0.48 mmHg; 95% CI -0.71 to -0.25.
Limitations
- Authors-reported systematic-review estimate; no platform synthesis.
Sources and exact versions
- Stable finding ID
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diastolic blood pressure
- AI-extracted — pending human review
- Source-authored record; platform synthesis is not enabled for this record.
- Publication status: published.
Exact source-reported results
Each record retains its source-reported context and uncertainty.
Studied context
- Authors-reported finding
- Authors reported WMD -0.12 mmHg; 95% CI -0.21 to -0.03.
Limitations
- Authors-reported systematic-review estimate; no platform synthesis.
Sources and exact versions
- Stable finding ID
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pulse wave velocity
- AI-extracted — pending human review
- Source-authored record; platform synthesis is not enabled for this record.
- Publication status: published.
Exact source-reported results
Each record retains its source-reported context and uncertainty.
Studied context
- Authors-reported finding
- Authors reported WMD -0.07 m/s; 95% CI -0.11 to -0.03.
Limitations
- Authors-reported systematic-review estimate; no platform synthesis.
Sources and exact versions
- Stable finding ID
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- Field locators
- reviewScope → https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text: abstract:2206-2257; doseIncrement → https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text: abstract:2272-2335; estimate → https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text: abstract:2942-3011
- https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text — document version pubmed:40128734:abstract:sha256:12b0fcea50185106b125a75cb776c65221ab4b08c503f8691fe399244fe01d0d — sha256:9fa9c22cf9d2039b4169ea503159726df670555b7e72ec39efcf0599913e0b5d
- reviewScope → abstract:2206-2257
- doseIncrement → abstract:2272-2335
- estimate → abstract:2942-3011
- reviewScope → abstract:2206-2257
- doseIncrement → abstract:2272-2335
- estimate → abstract:2942-3011
- sourceTopic.typedRole → Abstract, source context clause 1
- sourceTopic.typedRole → Abstract, source context clause 2
- sourceTopic.typedRole → Abstract, source context clause 3
- reviewScope → abstract:2206-2257
- doseIncrement → abstract:2272-2335
- estimate → abstract:2942-3011
- sourceTopic.typedRole → Abstract, source context clause 1
- sourceTopic.typedRole → Abstract, source context clause 2
- sourceTopic.typedRole → Abstract, source context clause 3
flow-mediated dilation
- AI-extracted — pending human review
- Source-authored record; platform synthesis is not enabled for this record.
- Publication status: published.
Exact source-reported results
Each record retains its source-reported context and uncertainty.
Studied context
- Authors-reported finding
- Authors reported WMD 0.3 %; 95% CI 0.15 to 0.46.
Limitations
- Authors-reported systematic-review estimate; no platform synthesis.
Sources and exact versions
- Stable finding ID
- finding:examine2025:40128734:8
- Source document version
- pubmed:40128734:abstract:sha256:12b0fcea50185106b125a75cb776c65221ab4b08c503f8691fe399244fe01d0d
- Finding revision
- finding:examine2025:40128734:8:v3
- Finding version
- 3
- Finding content hash
- sha256:6450cce329d89690b0215dddca8f69b3b9c04fa87a0cf25101158ed2654fb077
- Paper version
- 4
- Paper version content hash
- sha256:51b2b58760155eaafbb6f0e20245aa48ecc62d8b60cfeecb7a6a68e2327319c5
- Source content hash
- sha256:9fa9c22cf9d2039b4169ea503159726df670555b7e72ec39efcf0599913e0b5d
- Extraction policy
- context164-source-topic-policy:d2c863b8d9f94acf3a7378bfa6e49a23bd72eea4408a689b542d3f7244fd7bfb
- Extraction policy hash
- sha256:d2c863b8d9f94acf3a7378bfa6e49a23bd72eea4408a689b542d3f7244fd7bfb
- Extraction method version
- source-reported-records/v1
- Field locators
- reviewScope → https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text: abstract:2206-2257; doseIncrement → https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text: abstract:2272-2335; estimate → https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text: abstract:3013-3079
- https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text — document version pubmed:40128734:abstract:sha256:12b0fcea50185106b125a75cb776c65221ab4b08c503f8691fe399244fe01d0d — sha256:9fa9c22cf9d2039b4169ea503159726df670555b7e72ec39efcf0599913e0b5d
- reviewScope → abstract:2206-2257
- doseIncrement → abstract:2272-2335
- estimate → abstract:3013-3079
- reviewScope → abstract:2206-2257
- doseIncrement → abstract:2272-2335
- estimate → abstract:3013-3079
- sourceTopic.typedRole → Abstract, source context clause 1
- sourceTopic.typedRole → Abstract, source context clause 2
- sourceTopic.typedRole → Abstract, source context clause 3
- reviewScope → abstract:2206-2257
- doseIncrement → abstract:2272-2335
- estimate → abstract:3013-3079
- sourceTopic.typedRole → Abstract, source context clause 1
- sourceTopic.typedRole → Abstract, source context clause 2
- sourceTopic.typedRole → Abstract, source context clause 3
augmentation index
- AI-extracted — pending human review
- Source-authored record; platform synthesis is not enabled for this record.
- Publication status: published.
Exact source-reported results
Each record retains its source-reported context and uncertainty.
Studied context
- Authors-reported finding
- Authors reported WMD -0.57 %; 95% CI -0.98 to -0.15.
Limitations
- Authors-reported systematic-review estimate; no platform synthesis.
Sources and exact versions
- Stable finding ID
- finding:examine2025:40128734:9
- Source document version
- pubmed:40128734:abstract:sha256:12b0fcea50185106b125a75cb776c65221ab4b08c503f8691fe399244fe01d0d
- Finding revision
- finding:examine2025:40128734:9:v3
- Finding version
- 3
- Finding content hash
- sha256:9ab33cb26e15de9c111cc82b2624451c3693f4ac15edae09a6aea9a9018478cd
- Paper version
- 4
- Paper version content hash
- sha256:51b2b58760155eaafbb6f0e20245aa48ecc62d8b60cfeecb7a6a68e2327319c5
- Source content hash
- sha256:9fa9c22cf9d2039b4169ea503159726df670555b7e72ec39efcf0599913e0b5d
- Extraction policy
- context164-source-topic-policy:d2c863b8d9f94acf3a7378bfa6e49a23bd72eea4408a689b542d3f7244fd7bfb
- Extraction policy hash
- sha256:d2c863b8d9f94acf3a7378bfa6e49a23bd72eea4408a689b542d3f7244fd7bfb
- Extraction method version
- source-reported-records/v1
- Field locators
- reviewScope → https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text: abstract:2206-2257; doseIncrement → https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text: abstract:2272-2335; estimate → https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text: abstract:3085-3150
- https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=40128734&rettype=abstract&retmode=text — document version pubmed:40128734:abstract:sha256:12b0fcea50185106b125a75cb776c65221ab4b08c503f8691fe399244fe01d0d — sha256:9fa9c22cf9d2039b4169ea503159726df670555b7e72ec39efcf0599913e0b5d
- reviewScope → abstract:2206-2257
- doseIncrement → abstract:2272-2335
- estimate → abstract:3085-3150
- reviewScope → abstract:2206-2257
- doseIncrement → abstract:2272-2335
- estimate → abstract:3085-3150
- sourceTopic.typedRole → Abstract, source context clause 1
- sourceTopic.typedRole → Abstract, source context clause 2
- sourceTopic.typedRole → Abstract, source context clause 3
- reviewScope → abstract:2206-2257
- doseIncrement → abstract:2272-2335
- estimate → abstract:3085-3150
- sourceTopic.typedRole → Abstract, source context clause 1
- sourceTopic.typedRole → Abstract, source context clause 2
- sourceTopic.typedRole → Abstract, source context clause 3