Does Magnesium help mood? (Grade — evidence)
Explore current source-reported research for this exact question. These records are separate from the synthesis below; they do not update its grade or establish a recommendation.
Magnesium: the recorded evidence reports no meaningful benefit for mood. See the source and population limits.
Exact question reviewed
- Population
- not reported
- Intervention
- Magnesium
- Comparator
- not reported
- Outcome
- mood
- Time horizon
- not reported
Bottom line. Magnesium: the recorded evidence reports no meaningful benefit for mood. See the source and population limits. [1 SR/meta]
- Direction
- null
- Magnitude
- Not recommended for unipolar depression
- Grade
- —
- Certainty
- moderate
- Clinical meaning
- no established threshold
- Who it applies to
- —
- Dose / form studied
- not reported
- Safety
- minor_with_ssri
- The one limitation
- Claim-specific limitation details are not available in this public record.
Reviewed not reported · Evidence last changed · Open evidence record (version 0)
⚠ Safety in context
- minorwith SSRI: Generally fine with an SSRI; space about 2 hours apart. full interaction →
Grade or certainty not assigned — evidence bucket does not yet warrant a graded claim.
Who it works for
The studied population is not reported in this public record.
Evidence
| Study | Design | Role | Cite |
|---|---|---|---|
| Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce. | peer-reviewed | not classified | PMID:35311615 |
Why this grade
Reasoning trace
The current record stores Grade — at moderate certainty and links 1 publishable source. A claim-specific domain-by-domain grading rationale is not available in this public record, so no reason for upgrading or downgrading is inferred here.
Audit and version
- Claim ID
- ec_pmid:35311615#10
- Claim version
- not reported
- Governance
- legacy, not verified
- Clinician review
- Not yet reviewed by a licensed clinician
- Last evidence search
- not reported
- Last editorial review
- not verified
How it stacks up for mood
- Magnesium vs Vitamin D for mood — Vitamin D Grade C
- Magnesium vs St. John's Wort for mood — St. John's Wort Grade B
- Magnesium vs 5-HTP for mood — 5-HTP Grade C
- Magnesium vs N-Acetylcysteine for mood — N-Acetylcysteine Grade C
- Magnesium vs Saffron for mood — Saffron Grade B
- Magnesium vs Folate for mood — Folate Grade —
- All interventions graded for mood →
Grade history
No grade changes yet. Initial grade assigned; re-reviewed on every 6 months (Grade C+). Methodology v1.
Re-review cadence: every 6 months (Grade C+) · methodology v1.
Frequently asked
How long does Magnesium take to work for mood?
This record does not report a studied onset time for Magnesium and mood. Do not assume a typical timeframe.
What dose was used in studies of Magnesium for mood?
No studied dose is recorded for Magnesium and mood in this public record. See the dose block for what, if anything, is reported.
Does Magnesium work for mood if I'm not deficient?
The studied population is not reported for Magnesium and mood, so whether baseline status changes the effect is not known from this record.
Magnesium or the next-best alternative for mood?
See the compare block above for the head-to-head with the most-cited alternative. Grade + certainty differences matter more than any single trial.
Related
What this is — and is not
- Evidence description
- Not recommended for unipolar depression
- Substrate's interpretation
- The current reviewed record assigns Grade — at moderate certainty. A domain-by-domain rationale is shown only when recorded.
- Discuss with a clinician
- If you're on medication or have a condition that changes the calculus, bring the interaction & population blocks above to your pharmacist or prescriber before deciding.
- Individualized medical advice
- Not provided here or on any Substrate surface (API, agent tool, embed) — see YMYL policy.
Cite this page
Citation is encouraged. The proposed reuse license is CC-BY-4.0; status: pending-governance-ratification.
Plain-text citation
Substrate. Does Magnesium help mood?. https://evidencebased.info/interventions/magnesium/mood. Updated 2026-06-05.
BibTeX
@misc{substrate_entionsmagnesiummood,
author = {Substrate editorial},
title = {Does Magnesium help mood?},
year = {2026},
url = {https://evidencebased.info/interventions/magnesium/mood},
note = {evidencebased.info}
}Found something wrong on this page? Report an error →
Current source-reported research
Membership uses admitted intervention and measured-outcome associations for this exact question. Different populations, preparations, comparators and timepoints remain separate. No pooling or update to the synthesis is asserted.