Supplements for mood
Ranked by evidence grade. Nothing here is sold to you.
St. John's Wortgrade Bmoderate certainty— effective for mild-to-moderate depression in trials Saffrongrade Bmoderate certainty— multiple RCTs show benefit for mild-to-moderate depressive symptoms, comparable to low-dose SSRIs in small trials Vitamin Dgrade Clow certainty— small mood benefit, mostly in people who are deficient 5-HTPgrade Clow certainty— preliminary antidepressant signal; small, lower-quality studies N-Acetylcysteinegrade Clow certainty— preliminary evidence as an adjunct in some psychiatric conditions; not established as a standalone Omega-3grade Cmoderate certainty— small benefit for depressive symptoms, clearest with higher-EPA formulations Creatinegrade Clow certainty— emerging evidence as an adjunct for depressive symptoms; trials small Zincgrade Clow certainty— may augment antidepressant response; deficiency-correction likely matters Probioticsgrade Clow certainty— small effects on mood/anxiety in some "psychobiotic" trials; strain-specific, heterogeneous Turmericgrade Clow certainty— curcumin may reduce depressive symptoms as an adjunct; bioavailability-limited Folatestudied, no effectmoderate certainty— Folic acid not recommended for unipolar depression Vitamin Cstudied, no effectmoderate certainty— Not recommended for unipolar depression Myo-Inositolstudied, no effectmoderate certainty— Not recommended for unipolar depression Magnesiumstudied, no effectmoderate certainty— Not recommended for unipolar depression Rhodiolastudied, no effectmoderate certainty— Not recommended for mood disorders