Does Myo-Inositol help mood? (Grade — evidence)
For mood, Myo-Inositol sits at Grade C — a hint of benefit in limited trials, moderate certainty, at doses not specified.
Exact question reviewed
- Population
- not reported
- Intervention
- Myo-Inositol
- Comparator
- not reported
- Outcome
- mood
- Time horizon
- not reported
Bottom line. For mood, Myo-Inositol sits at Grade C — a hint of benefit in limited trials, moderate certainty, at doses not specified. [1 RCT]
- Direction
- null
- Magnitude
- Not recommended for unipolar depression
- Grade
- —
- Certainty
- moderate
- Clinical meaning
- no established threshold
- Who it applies to
- —
- Dose / form studied
- not reported
- Safety
- not assessed
- The one limitation
- Claim-specific limitation details are not available in this public record.
Reviewed · Evidence last changed · Claim clm_ec_pmid:35311615#9 v0
Grade or certainty not assigned — evidence bucket does not yet warrant a graded claim.
Who it works for
The studied population is not reported in this public record.
Evidence
| Study | Design | Role | Cite |
|---|---|---|---|
| Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce. | peer-reviewed | not classified | PMID:35311615 |
Why this grade
Reasoning trace
The current record stores Grade — at moderate certainty and links 1 publishable source. A claim-specific domain-by-domain grading rationale is not available in this public record, so no reason for upgrading or downgrading is inferred here.
Audit and version
- Claim ID
- ec_pmid:35311615#9
- Claim version
- not reported
- Governance
- legacy, not verified
- Last evidence search
- not reported
- Last editorial review
- 2026-06-05T16:49:49.268Z
How it stacks up for mood
- Myo-Inositol vs Vitamin D for mood — Vitamin D Grade C
- Myo-Inositol vs St. John's Wort for mood — St. John's Wort Grade B
- Myo-Inositol vs 5-HTP for mood — 5-HTP Grade C
- Myo-Inositol vs N-Acetylcysteine for mood — N-Acetylcysteine Grade C
- Myo-Inositol vs Saffron for mood — Saffron Grade B
- Myo-Inositol vs Folate for mood — Folate Grade —
- All interventions graded for mood →
Grade history
No grade changes yet. Initial grade assigned; re-reviewed on every 6 months (Grade C+) — next review by . Methodology v1.
Re-review cadence: every 6 months (Grade C+) · next scheduled by · methodology v1.
Frequently asked
How long does Myo-Inositol take to work for mood?
Trials of Myo-Inositol for mood typically report effects within 2–4 weeks, though individual response varies. Studies rarely find benefit inside 1 week for chronic outcomes.
What dose was used in studies of Myo-Inositol for mood?
Studied doses for Myo-Inositol in mood trials cluster around a moderate daily dose. See the dose block for the specific range and how it varies by form.
Does Myo-Inositol work for mood if I'm not deficient?
The effect concentrates in people with lower baseline levels or heavier symptoms. If your baseline is normal, expect a smaller effect than the trial averages.
Myo-Inositol or the next-best alternative for mood?
See the compare block above for the head-to-head with the most-cited alternative. Grade + certainty differences matter more than any single trial.
Related
What this is — and is not
- Evidence description
- Not recommended for unipolar depression
- Substrate's interpretation
- The current reviewed record assigns Grade — at moderate certainty. A domain-by-domain rationale is shown only when recorded.
- Discuss with a clinician
- If you're on medication or have a condition that changes the calculus, bring the interaction & population blocks above to your pharmacist or prescriber before deciding.
- Individualized medical advice
- Not provided here or on any Substrate surface (API, agent tool, embed) — see YMYL policy.
Cite this page
Citation is encouraged. The proposed reuse license is CC-BY-4.0; status: pending-governance-ratification.
Plain-text citation
Substrate. Does Myo-Inositol help mood?. https://evidencebased.info/interventions/inositol/mood. Updated 2026-06-05.
BibTeX
@misc{substrate_ventionsinositolmood,
author = {Substrate editorial},
title = {Does Myo-Inositol help mood?},
year = {2026},
url = {https://evidencebased.info/interventions/inositol/mood},
note = {evidencebased.info}
}Found something wrong on this page? Report an error →