Magnesium vs Rhodiola

for mood

Stronger evidence: tie

Stronger effect: tie

Safety: Rhodiola has the more serious interaction profile (minor vs uncertain).

For mood, the two are evidence-matched; the difference is in effect and safety.

Magnesium

studied, no effect moderate certainty

Not recommended for unipolar depression

Rhodiola

studied, no effect moderate certainty

Not recommended for mood disorders

sources: PMID:35311615 · PMID:35311615