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interventions / Vitamin D / migraine frequency

Does Vitamin D help migraine frequency? (Grade B evidence)

Explore current source-reported research for this exact question. These records are separate from the synthesis below; they do not update its grade or establish a recommendation.

Grade B for Vitamin D on migraine frequency: the balance of recorded evidence favours a benefit, especially in adults with migraine, at moderate certainty, at doses varies across trials.

Exact question reviewed

Population
adults with migraine
Intervention
Vitamin D · varies across trials
Comparator
not reported
Outcome
migraine frequency
Time horizon
not reported

Bottom line. Grade B for Vitamin D on migraine frequency: the balance of recorded evidence favours a benefit, especially in adults with migraine, at moderate certainty, at doses varies across trials. [1 SR/meta]

Direction
benefit
Magnitude
Meta-analysis of 5 RCTs: vitamin D treatment significantly reduced headache days, attack frequency, headache severity, and migraine-related disability versus control in migraine patients. One of the more consistent positive signals for a vitamin D outcome in this dataset, though the evidence base is still just 5 trials.
Grade
B
Certainty
moderate
Clinical meaning
small but potentially useful
Who it applies to
adults with migraine
Dose / form studied
varies across trials
Safety
not assessed
The one limitation
Claim-specific limitation details are not available in this public record.

Reviewed not reported · Evidence last changed · Open evidence record (version 0)

Grade
B
what does the grade mean?
Certainty
moderate
what does certainty mean?

Grade B / moderate: probably helps, and new studies are unlikely to reverse this — but could shrink the effect size.

Who it works for

Best-studied in adults with migraine. Recorded studied dose: varies across trials.

Evidence

StudyDesignRoleCite
The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies.peer-reviewedsupportsPMID:33449474

Why this grade

Reasoning trace

The current record stores Grade B at moderate certainty and links 1 publishable source. A claim-specific domain-by-domain grading rationale is not available in this public record, so no reason for upgrading or downgrading is inferred here.

Audit and version

Claim ID
ec_b10-vitd-migraine
Claim version
not reported
Governance
legacy, not verified
Clinician review
Not yet reviewed by a licensed clinician
Last evidence search
not reported
Last editorial review
not verified

Public receipt · Machine-readable claim · Methodology

Dose & form

Studied intake: varies across trials.

How it stacks up for migraine frequency

Grade history

No grade changes yet. Initial grade assigned; re-reviewed on every 12 months (Grade A/B). Methodology v1.

Re-review cadence: every 12 months (Grade A/B) · methodology v1.

Frequently asked

How long does Vitamin D take to work for migraine frequency?

This record does not report a studied onset time for Vitamin D and migraine frequency. Do not assume a typical timeframe.

What dose was used in studies of Vitamin D for migraine frequency?

The recorded studied dose for Vitamin D and migraine frequency is varies across trials. This is a source detail, not a dose recommendation.

Does Vitamin D work for migraine frequency if I'm not deficient?

The recorded studied population is adults with migraine. This field alone does not show whether deficiency or baseline status changes the effect.

Vitamin D or the next-best alternative for migraine frequency?

See the compare block above for the head-to-head with the most-cited alternative. Grade + certainty differences matter more than any single trial.

Related

What this is — and is not

Evidence description
Meta-analysis of 5 RCTs: vitamin D treatment significantly reduced headache days, attack frequency, headache severity, and migraine-related disability versus control in migraine patients. One of the more consistent positive signals for a vitamin D outcome in this dataset, though the evidence base is still just 5 trials.
Substrate's interpretation
The current reviewed record assigns Grade B at moderate certainty. A domain-by-domain rationale is shown only when recorded.
Discuss with a clinician
If you're on medication or have a condition that changes the calculus, bring the interaction & population blocks above to your pharmacist or prescriber before deciding.
Individualized medical advice
Not provided here or on any Substrate surface (API, agent tool, embed) — see YMYL policy.

Cite this page

Citation is encouraged. The proposed reuse license is CC-BY-4.0; status: pending-governance-ratification.

Plain-text citation
Substrate. Does Vitamin D help migraine frequency? (Grade B). https://evidencebased.info/interventions/vitamin-d/migraine. Updated 2026-07-16.
BibTeX
@misc{substrate_ionsvitamindmigraine,
  author = {Substrate editorial},
  title  = {Does Vitamin D help migraine frequency?},
  year   = {2026},
  url    = {https://evidencebased.info/interventions/vitamin-d/migraine},
  note   = {Grade B, evidencebased.info}
}

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Current source-reported research

Membership uses admitted intervention and measured-outcome associations for this exact question. Different populations, preparations, comparators and timepoints remain separate. No pooling or update to the synthesis is asserted.