Vitamin D vs Saffron

for mood

Stronger evidence: Saffron

Stronger effect: Saffron

Safety: Vitamin D carries a minor interaction; Saffron has none recorded.

For mood, Saffron has the stronger evidence grade.

grade C low certainty

small mood benefit, mostly in people who are deficient

grade B moderate certainty

multiple RCTs show benefit for mild-to-moderate depressive symptoms, comparable to low-dose SSRIs in small trials

30 mg/day, adults with mild-moderate depression

sources: PMID:00000005 · PMID:10000003