Substrate ·evidence-based
compare / Vitamin D vs Folate

Vitamin D vs Folate

for mood

Stronger evidence: Vitamin D

Stronger effect: Vitamin D

Safety: Vitamin D carries a minor interaction; Folate has none recorded.

For mood, Vitamin D has the stronger evidence grade.

Vitamin D

grade C low certainty

small mood benefit, mostly in people who are deficient

Folate

studied, no effect moderate certainty

Folic acid not recommended for unipolar depression

sources: PMID:00000005 · PMID:35311615