St. John's Wort vs Folate

for mood

Stronger evidence: St. John's Wort

Stronger effect: St. John's Wort

Safety: St. John's Wort carries a contraindicated interaction; Folate has none recorded.

For mood, St. John's Wort has the stronger evidence grade.

grade B moderate certainty

effective for mild-to-moderate depression in trials

300 mg ×3/day, adults, mild-to-moderate depression

studied, no effect moderate certainty

Folic acid not recommended for unipolar depression

sources: PMID:00000009 · PMID:35311615