Magnesium vs Melatonin for migraine frequency: which has better evidence?
A tie on evidence grade for migraine frequency (Magnesium Grade C vs Melatonin Grade C). For migraine frequency, the two are evidence-matched; the difference is in effect and safety.
Platform evidence comparison
These existing platform assessments are separate from the source-reported findings below. They do not represent a direct trial comparing these treatments.
| Magnesium | Melatonin | |
|---|---|---|
| Grade | grade C | grade C |
| Certainty | low | low |
| Effect | 10 oral-magnesium RCTs (n=789): reduced migraine frequency and intensity vs. placebo (odds ratios 0.20 and 0.27, no CIs given); some trials had inadequate randomization per the review authors. A separate IV arm covered acute attacks, not prevention. | Systematic review: melatonin showed promise for migraine prophylaxis, reducing attack frequency in several trials, with a tolerability profile comparable to or better than some standard preventives. The evidence base is small and heterogeneous. |
| Studied dose | not standardized across the 10 oral trials | commonly 3 mg at night in the trials |
| Population | adults with migraine, oral prophylaxis | adults with migraine, prophylaxis |
| Safety | 1 modeled interaction(s) | 1 modeled interaction(s) |
Grade C / low: hints of benefit in small trials; a well-run RCT could easily push this to B or to null.
Direct comparison evidence
There are no direct RCTs in our corpus comparing Magnesium and Melatonin head-to-head for migraine frequency. What we present above is an indirect comparison: each side's own trials, contrasted. This is standard practice for supplement comparisons — dose, population, and outcome-instrument differences between the two evidence bases add uncertainty on top of each side's own grade.
Can you take both?
No modeled interaction between Magnesium and Melatonin in our corpus. Absence of a recorded interaction is not proof of additive benefit — combined-effect trials are usually absent for supplement pairs, so treat "stack" claims skeptically.
Decision guidance
- If certainty matters most — choose whichever side carries the higher certainty rating at a similar grade.
- If you're on medications — check each side's interaction pages before deciding; safety differences dominate small evidence-grade gaps.
- If your population is under-studied — the smaller-effect side with better population evidence often wins over the higher-grade side studied in a different demographic.
- If cost matters — form and dose page differences (Magnesium vs Melatonin) can invert the practical winner.
Grade history
No grade changes yet. Initial grade assigned; re-reviewed on every 6 months (Grade C+) — next review by . Methodology v1.
Re-review cadence: every 6 months (Grade C+) · next scheduled by · methodology v1.
Frequently asked
Which has stronger evidence: Magnesium or Melatonin for migraine frequency?
Magnesium carries Grade C at low certainty; Melatonin carries Grade C at low. The stronger evidence points to a tie, subject to the caveat that direct head-to-head trials are usually absent for supplement pairings.
Can I take Magnesium and Melatonin together?
No modeled interaction between Magnesium and Melatonin; combining is not documented to be problematic, but combined-effect trials are also absent, so treat additive benefit claims skeptically.
Have Magnesium and Melatonin been compared head-to-head?
Direct RCTs comparing the two for migraine frequency are uncommon. This page contrasts each side's own trial evidence — that is an indirect comparison, which introduces confounds from population and dose differences. See the direct-comparison block above.
What decides between Magnesium and Melatonin for me?
Read the decision guidance below — the split usually comes down to population fit, interaction risk with your other medications, and how much certainty you want behind the recommendation.
Related
Cite this page
Citation is encouraged. The proposed reuse license is CC-BY-4.0; status: pending-governance-ratification.
Plain-text citation
Substrate. Magnesium vs Melatonin for migraine frequency. https://evidencebased.info/compare/magnesium-vs-melatonin-for-migraine. Updated 2026-07-14.
BibTeX
@misc{substrate_melatoninformigraine,
author = {Substrate editorial},
title = {Magnesium vs Melatonin for migraine frequency},
year = {2026},
url = {https://evidencebased.info/compare/magnesium-vs-melatonin-for-migraine},
note = {evidencebased.info}
}