St. John's Wort for mood: B → B
Merged additional source by Claude (gold-standard provenance sweep): a distinct, independently-verified paper ("A systematic review of St. John's wort for major depressive disorder.", PMID 27589952) reporting the same intervention×outcome was found instead of being discarded as a duplicate — same claim, one more piece of real evidence.
What triggered this change
A systematic review of St. John's wort for major depressive disorder.. Read: Substrate breakdown · PubMed.
What we said before vs now
Before
Grade B
After
Grade B
effective for mild-to-moderate depression in trials
What this does not change
- Interaction profile for St. John's Wort — unchanged unless there is a separate severity change.
- Dose guidance — unchanged unless the new evidence altered the studied dose range.
- Safety recommendations — unchanged unless a safety event is recorded separately.
Reviewer & methodology
Reviewed and signed by Substrate editorial (Independent research collective) on . Methodology v1.
See also
Cite this page
Reuse under CC-BY 4.0 with attribution to evidencebased.info.
Plain-text citation
Substrate. St. John's Wort for mood: B → B. https://evidencebased.info/changes/2026-07-16-st-johns-wort-mood-b-to-b. Updated 2026-07-16.
BibTeX
@misc{substrate_6stjohnswortmoodbtob,
author = {Substrate editorial},
title = {St. John's Wort for mood: B → B},
year = {2026},
url = {https://evidencebased.info/changes/2026-07-16-st-johns-wort-mood-b-to-b},
note = {evidencebased.info}
}