St. John's Wort: what the evidence actually shows
settled St. John's Wort — established for mild depression; interaction-heavy
Reviewer and governance status are shown on each atomic claim below.
What it is
St. John's Wort is tracked as a health intervention in this evidence graph. Also known as: Hypericum perforatum, hypericum, perforatum.
Studied forms and doses
No form-specific catalog record is available. This does not mean all forms are equivalent.
- mood: 300 mg ×3/day; form not reported.
Mechanisms
Mechanistic plausibility is context, not proof that a clinical outcome improves.
No structured mechanism is recorded.
⚠ Safety in context
- contraindicatedwith SSRI: St. John's Wort with an SSRI risks serotonin syndrome — do not combine.
- moderatewith Ashwagandha: Two serotonergic/sedating botanicals together may have additive effects.
Products and verification
No product label snapshot is mapped in this released catalog. Ingredient evidence does not establish any bottle’s identity, potency, purity, availability, or value.
Evidence by outcome
Grade history
- B → BMerged additional source by Claude (gold-standard provenance sweep): a distinct, independently-verified paper ("A systematic review of St. J details →
- B → BCorrection by Claude (gold-standard provenance sweep): live Postgres source drift replaced with the verified seed source set [pmid:18843608] details →
Re-review cadence: every 12 months (Grade A/B) · next scheduled by · methodology v1.
By outcome — the money pages
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More
Cite this page
Citation is encouraged. The proposed reuse license is CC-BY-4.0; status: pending-governance-ratification.
Plain-text citation
Substrate. St. John's Wort: what the evidence actually shows. https://evidencebased.info/interventions/st-johns-wort. Updated 2026-07-16.
BibTeX
@misc{substrate_rventionsstjohnswort,
author = {Substrate editorial},
title = {St. John's Wort: what the evidence actually shows},
year = {2026},
url = {https://evidencebased.info/interventions/st-johns-wort},
note = {evidencebased.info}
}