Supplements for skin
Compared by effect and evidence certainty. Cost is not currently assessed, and nothing here is sold to you.
Collagengrade Clow certainty— small improvements in skin elasticity/hydration in industry-funded trials Safety: no modeled interaction found; coverage unknown, not proven safe. Cost: not assessed. Evidence gaps: population bounds not reported; certainty or evidence strength remains limited.
Zincgrade Clow certainty— Acquired zinc deficiency is deeply involved in the development of skin diseases including acquired acrodermatitis enteropathica, necrolytic migratory erythema, alopecia, and delayed wound healing, and mutations or dysregulation in zinc transporters are associated with skin manifestations. Safety: no modeled interaction found; coverage unknown, not proven safe. Cost: not assessed. Evidence gaps: studied dose not reported; population bounds not reported; certainty or evidence strength remains limited.
Vitamin Cgrade Clow certainty— topical better-supported than oral; oral may support collagen synthesis Safety: no modeled interaction found; coverage unknown, not proven safe. Cost: not assessed. Evidence gaps: certainty or evidence strength remains limited.
Zincgrade Clow certainty— Systematic review and meta-analysis: people with acne tended to have lower serum zinc levels, and zinc treatment modestly reduced acne lesion counts versus control. Trials were heterogeneous in dose and form, so certainty is low. Safety: no modeled interaction found; coverage unknown, not proven safe. Cost: not assessed. Evidence gaps: certainty or evidence strength remains limited.
Turmericgrade Clow certainty— Systematic review of clinical studies of turmeric/curcumin (oral and topical) across skin conditions (acne, atopic dermatitis, psoriasis, photoaging, pruritus and others): several studies reported significant improvement in disease severity versus control, but the authors characterize this as early evidence from a limited set of studies needing further confirmation. Safety: moderate — High-dose curcumin may have mild antiplatelet effects; caution with warfarin.. Cost: not assessed. Evidence gaps: certainty or evidence strength remains limited.
Probioticsgrade Clow certainty— Meta-analysis (21 studies): probiotic supplementation lowered the risk of eczema and atopic eczema in children versus control, with the effect strongest for probiotic combinations and for maternal intake during pregnancy. Benefit is specifically eczema PREVENTION in early childhood — no significant effect on asthma, rhinitis or other allergic outcomes, and this is not a treatment claim for adult skin. Safety: no modeled interaction found; coverage unknown, not proven safe. Cost: not assessed. Evidence gaps: certainty or evidence strength remains limited.
Omega-3grade Dvery-low certainty— Narrative review: omega-3 fatty acids have plausible dermatological roles (skin barrier, inflammation modulation, photoprotection), but controlled clinical evidence that supplementation improves specific skin outcomes is limited and preliminary. Safety: serious — High-dose omega-3 with warfarin may increase bleeding risk.. Cost: not assessed. Evidence gaps: certainty or evidence strength remains limited.