Omega-3 vs Probiotics

for mood

Stronger evidence: tie

Stronger effect: Omega-3

Safety: Omega-3 carries a serious interaction; Probiotics has none recorded.

For mood, the two are evidence-matched; the difference is in effect and safety.

grade C moderate certainty

small benefit for depressive symptoms, clearest with higher-EPA formulations

1–2 g EPA, adults with depression

grade C low certainty

small effects on mood/anxiety in some "psychobiotic" trials; strain-specific, heterogeneous

strain-dependent, adults

sources: PMID:20000102 · PMID:42221774