Folate vs Zinc

for mood

Stronger evidence: Zinc

Stronger effect: Zinc

Safety: No notable interactions recorded for either.

For mood, Zinc has the stronger evidence grade.

studied, no effect moderate certainty

Folic acid not recommended for unipolar depression

grade C low certainty

may augment antidepressant response; deficiency-correction likely matters

25 mg/day, adults

sources: PMID:35311615 · PMID:42197650