Folate vs Probiotics

for mood

Stronger evidence: Probiotics

Stronger effect: Probiotics

Safety: No notable interactions recorded for either.

For mood, Probiotics has the stronger evidence grade.

studied, no effect moderate certainty

Folic acid not recommended for unipolar depression

grade C low certainty

small effects on mood/anxiety in some "psychobiotic" trials; strain-specific, heterogeneous

strain-dependent, adults

sources: PMID:35311615 · PMID:42221774