Folate vs Omega-3

for mood

Stronger evidence: Omega-3

Stronger effect: Omega-3

Safety: Omega-3 carries a serious interaction; Folate has none recorded.

For mood, Omega-3 has the stronger evidence grade.

studied, no effect moderate certainty

Folic acid not recommended for unipolar depression

grade C moderate certainty

small benefit for depressive symptoms, clearest with higher-EPA formulations

1–2 g EPA, adults with depression

sources: PMID:35311615 · PMID:20000102