Creatine vs Zinc
for mood
Stronger evidence: tie
Stronger effect: tie
Safety: No notable interactions recorded for either.
For mood, the two are evidence-matched; the difference is in effect and safety.
Creatine
grade C low certainty
emerging evidence as an adjunct for depressive symptoms; trials small
3–5 g/day, adults with depression
Zinc
grade C low certainty
may augment antidepressant response; deficiency-correction likely matters
25 mg/day, adults
sources: PMID:42180567 · PMID:42197650