Creatine vs Probiotics
for mood
Stronger evidence: tie
Stronger effect: tie
Safety: No notable interactions recorded for either.
For mood, the two are evidence-matched; the difference is in effect and safety.
Creatine
grade C low certainty
emerging evidence as an adjunct for depressive symptoms; trials small
3–5 g/day, adults with depression
Probiotics
grade C low certainty
small effects on mood/anxiety in some "psychobiotic" trials; strain-specific, heterogeneous
strain-dependent, adults
sources: PMID:42180567 · PMID:42221774