Vitamin C for cold prevention: C → null-result
Meta-analysis confirmed no prevention benefit in the general population; regraded to null-result.
What we said before vs now
Before
Grade C
After
Grade null-result
no reduction in cold incidence in the general population
What this does not change
- Interaction profile for Vitamin C — unchanged unless there is a separate severity change.
- Dose guidance — unchanged unless the new evidence altered the studied dose range.
- Safety recommendations — unchanged unless a safety event is recorded separately.
Reviewer & methodology
Reviewed and signed by Substrate editorial (Independent research collective) on . Methodology v1.
See also
Cite this page
Citation is encouraged. The proposed reuse license is CC-BY-4.0; status: pending-governance-ratification.
Plain-text citation
Substrate. Vitamin C for cold prevention: C → null-result. https://evidencebased.info/changes/2026-04-12-vitamin-c-cold-prevention-c-to-x. Updated 2026-04-12.
BibTeX
@misc{substrate_nccoldpreventionctox,
author = {Substrate editorial},
title = {Vitamin C for cold prevention: C → null-result},
year = {2026},
url = {https://evidencebased.info/changes/2026-04-12-vitamin-c-cold-prevention-c-to-x},
note = {evidencebased.info}
}