Zinc

settled  zinc — established for cold duration at the right dose and timing

Evidence by outcome

cold preventiongrade Bmoderate certaintyzinc lozenges started early may modestly shorten cold duration
immune functiongrade Clow certaintysupplementation helps mainly when intake is deficient
cold preventiongrade Cmoderate certaintyzinc lozenges started early may shorten common-cold duration
moodgrade Clow certaintymay augment antidepressant response; deficiency-correction likely matters
skingrade Clow certaintyAcquired zinc deficiency is deeply involved in the development of skin diseases including acquired acrodermatitis enteropathica, necrolytic migratory erythema, alopecia, and delayed wound healing, and mutations or dysregulation in zinc transporters are associated with skin manifestations.

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sources: PMID:00000023 · PMID:00000024 · PMID:20000111 · PMID:42197650 · PMID:29439479