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interventions / Ginkgo / inflammation

Does Ginkgo help inflammation? (Grade B evidence)

Explore current source-reported research for this exact question. These records are separate from the synthesis below; they do not update its grade or establish a recommendation.

Ginkgo probably helps inflammation (Grade B, moderate certainty), especially in adults, especially with elevated baseline inflammation. Studied doses: best evidence at doses under 500 mg/day.

Exact question reviewed

Population
adults, especially with elevated baseline inflammation
Intervention
Ginkgo · best evidence at doses under 500 mg/day
Comparator
not reported
Outcome
inflammation
Time horizon
not reported

Bottom line. Ginkgo probably helps inflammation (Grade B, moderate certainty), especially in adults, especially with elevated baseline inflammation. Studied doses: best evidence at doses under 500 mg/day. [1 SR/meta]

Direction
benefit
Magnitude
Systematic review and meta-analysis of 17 RCTs (1104 participants): Ginkgo biloba leaf extract significantly reduced serum CRP, IL-6, and TNF-alpha versus placebo. Effect on CRP was strongest at higher baseline inflammation (CRP ≥3 mg/L) and lower doses (<500 mg/day). One of the more consistent anti-inflammatory signals in this dataset.
Grade
B
Certainty
moderate
Clinical meaning
small but potentially useful
Who it applies to
adults, especially with elevated baseline inflammation
Dose / form studied
best evidence at doses under 500 mg/day
Safety
serious_with_warfarin; moderate_with_ssri
The one limitation
Claim-specific limitation details are not available in this public record.

Reviewed not reported · Evidence last changed · Open evidence record (version 0)

⚠ Safety in context

Grade
B
what does the grade mean?
Certainty
moderate
what does certainty mean?

Grade B / moderate: probably helps, and new studies are unlikely to reverse this — but could shrink the effect size.

Who it works for

Best-studied in adults, especially with elevated baseline inflammation. Recorded studied dose: best evidence at doses under 500 mg/day.

Evidence

StudyDesignRoleCite
Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: A systematic review and meta-analysis of the clinical trials.peer-reviewedsupportsPMID:35781715

Why this grade

Reasoning trace

The current record stores Grade B at moderate certainty and links 1 publishable source. A claim-specific domain-by-domain grading rationale is not available in this public record, so no reason for upgrading or downgrading is inferred here.

Audit and version

Claim ID
ec_b13-ginkgo-inflammation
Claim version
not reported
Governance
legacy, not verified
Clinician review
Not yet reviewed by a licensed clinician
Last evidence search
not reported
Last editorial review
not verified

Public receipt · Machine-readable claim · Methodology

Dose & form

Studied intake: best evidence at doses under 500 mg/day.

How it stacks up for inflammation

Grade history

No grade changes yet. Initial grade assigned; re-reviewed on every 12 months (Grade A/B). Methodology v1.

Re-review cadence: every 12 months (Grade A/B) · methodology v1.

Frequently asked

How long does Ginkgo take to work for inflammation?

This record does not report a studied onset time for Ginkgo and inflammation. Do not assume a typical timeframe.

What dose was used in studies of Ginkgo for inflammation?

The recorded studied dose for Ginkgo and inflammation is best evidence at doses under 500 mg/day. This is a source detail, not a dose recommendation.

Does Ginkgo work for inflammation if I'm not deficient?

The recorded studied population is adults, especially with elevated baseline inflammation. This field alone does not show whether deficiency or baseline status changes the effect.

Ginkgo or the next-best alternative for inflammation?

See the compare block above for the head-to-head with the most-cited alternative. Grade + certainty differences matter more than any single trial.

Related

What this is — and is not

Evidence description
Systematic review and meta-analysis of 17 RCTs (1104 participants): Ginkgo biloba leaf extract significantly reduced serum CRP, IL-6, and TNF-alpha versus placebo. Effect on CRP was strongest at higher baseline inflammation (CRP ≥3 mg/L) and lower doses (<500 mg/day). One of the more consistent anti-inflammatory signals in this dataset.
Substrate's interpretation
The current reviewed record assigns Grade B at moderate certainty. A domain-by-domain rationale is shown only when recorded.
Discuss with a clinician
If you're on medication or have a condition that changes the calculus, bring the interaction & population blocks above to your pharmacist or prescriber before deciding.
Individualized medical advice
Not provided here or on any Substrate surface (API, agent tool, embed) — see YMYL policy.

Cite this page

Citation is encouraged. The proposed reuse license is CC-BY-4.0; status: pending-governance-ratification.

Plain-text citation
Substrate. Does Ginkgo help inflammation? (Grade B). https://evidencebased.info/interventions/ginkgo/inflammation. Updated 2026-07-16.
BibTeX
@misc{substrate_nsginkgoinflammation,
  author = {Substrate editorial},
  title  = {Does Ginkgo help inflammation?},
  year   = {2026},
  url    = {https://evidencebased.info/interventions/ginkgo/inflammation},
  note   = {Grade B, evidencebased.info}
}

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Current source-reported research

Membership uses admitted intervention and measured-outcome associations for this exact question. Different populations, preparations, comparators and timepoints remain separate. No pooling or update to the synthesis is asserted.