Folate: what the evidence actually shows
Reviewer and governance status are shown on each atomic claim below.
What it is
Folate is tracked as a health intervention in this evidence graph. Also known as: folic acid.
Studied forms and doses
No form-specific catalog record is available. This does not mean all forms are equivalent.
- prenatal / neural-tube health: 400 mcg/day; form not reported.
Mechanisms
Mechanistic plausibility is context, not proof that a clinical outcome improves.
No structured mechanism is recorded.
⚠ Safety in context
No interaction record is modeled for this intervention. This is an unknown coverage state, not evidence that no interaction exists.
Products and verification
No product label snapshot is mapped in this released catalog. Ingredient evidence does not establish any bottle’s identity, potency, purity, availability, or value.
Evidence by outcome
What it probably doesn't do
- Folate for mood — Grade —, Folic acid not recommended for unipolar depression.
Grade history
- A → ACorrection by Claude (gold-standard provenance sweep): live Postgres source drift replaced with the verified seed source set [pmid:26662928] details →
- A → AMerged additional source by Claude (gold-standard provenance sweep): a distinct, independently-verified paper ("Effects and safety of perico details →
Re-review cadence: every 12 months (Grade A/B) · next scheduled by · methodology v1.
By outcome — the money pages
Compare
- Folate vs Vitamin D for mood
- Folate vs St. John's Wort for mood
- Folate vs 5-HTP for mood
- Folate vs N-Acetylcysteine for mood
- Folate vs Saffron for mood
- Folate vs Vitamin C for mood
- Folate vs Myo-Inositol for mood
- Folate vs Magnesium for mood
- Folate vs Rhodiola for mood
- Folate vs Omega-3 for mood
- Folate vs Creatine for mood
- Folate vs Zinc for mood
- Folate vs Probiotics for mood
- Folate vs Turmeric for mood
- Folate vs Ginkgo for mood
- Folate vs Melatonin for mood
- Folate vs Lion's Mane for mood
- Folate vs Ashwagandha for mood
More
Cite this page
Citation is encouraged. The proposed reuse license is CC-BY-4.0; status: pending-governance-ratification.
Plain-text citation
Substrate. Folate: what the evidence actually shows. https://evidencebased.info/interventions/folate. Updated 2026-07-16.
BibTeX
@misc{substrate_ointerventionsfolate,
author = {Substrate editorial},
title = {Folate: what the evidence actually shows},
year = {2026},
url = {https://evidencebased.info/interventions/folate},
note = {evidencebased.info}
}