Folate: what the evidence actually shows
Evidence by outcome
prenatal / neural-tube healthgrade Ahigh certainty— periconceptional folic acid substantially reduces neural-tube-defect risk
moodstudied, no effectmoderate certainty— Folic acid not recommended for unipolar depression
What it probably doesn't do
- Folate for mood — Grade —, Folic acid not recommended for unipolar depression.
Grade history
- A → ACorrection by Claude (gold-standard provenance sweep): live Postgres source drift replaced with the verified seed source set [pmid:26662928] details →
- A → AMerged additional source by Claude (gold-standard provenance sweep): a distinct, independently-verified paper ("Effects and safety of perico details →
Re-review cadence: every 12 months (Grade A/B) · next scheduled by · methodology v1.
By outcome — the money pages
Compare
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- Folate vs Probiotics for mood
- Folate vs Turmeric for mood
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More
sources: PMID:26662928 · PMID:35311615
Cite this page
Reuse under CC-BY 4.0 with attribution to evidencebased.info.
Plain-text citation
Substrate. Folate: what the evidence actually shows. https://evidencebased.info/interventions/folate. Updated 2026-07-16.
BibTeX
@misc{substrate_ointerventionsfolate,
author = {Substrate editorial},
title = {Folate: what the evidence actually shows},
year = {2026},
url = {https://evidencebased.info/interventions/folate},
note = {evidencebased.info}
}