5-HTP
settled 5-HTP — niche; modest evidence and a real serotonergic interaction risk
⚠ Safety in context
- seriouswith SSRI: 5-HTP raises serotonin; with an SSRI this risks serotonin syndrome. Do not combine without medical supervision.
Evidence by outcome
moodgrade Clow certainty— preliminary antidepressant signal; small, lower-quality studies
sleepgrade Clow certainty— limited evidence for sleep; serotonergic, so caution with antidepressants
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sources: PMID:00000035 · PMID:00000036