Rhodiola vs Vitamin B12

for energy / fatigue

Stronger evidence: tie

Stronger effect: Vitamin B12

Safety: Rhodiola carries a uncertain interaction; Vitamin B12 has none recorded.

For energy / fatigue, the two are evidence-matched; the difference is in effect and safety.

grade C low certainty

small reductions in fatigue in stressed adults; studies are short and small

grade C low certainty

corrects fatigue when B12 deficiency is present; no energy benefit in replete people

RDA-to-high oral, adults

sources: PMID:00000031 · PMID:10000010