Melatonin vs Saffron

for sleep

Stronger evidence: Melatonin

Stronger effect: Melatonin

Safety: Melatonin carries a uncertain interaction; Saffron has none recorded.

For sleep, Melatonin has the stronger evidence grade.

grade B moderate certainty

reduces time to fall asleep; best for circadian timing

0.5–3 mg

grade C low certainty

small RCTs suggest improved sleep quality

30 mg/day, adults

sources: PMID:00000006 · PMID:41901246