Lion's Mane vs Ashwagandha
for cognition
Stronger evidence: tie
Stronger effect: Ashwagandha
Safety: Ashwagandha carries a moderate interaction; Lion's Mane has none recorded.
For cognition, the two are evidence-matched; the difference is in effect and safety.
Lion's Mane
grade C low certainty
early, small studies suggest a modest cognitive effect
~1 g/day, adults
Ashwagandha
grade C low certainty
preliminary improvements in memory/executive function; small trials
300–600 mg/day, adults
sources: PMID:00000010 · PMID:42220661