Creatine vs Lion's Mane

for cognition

Stronger evidence: Creatine

Stronger effect: Creatine

Safety: No notable interactions recorded for either.

For cognition, Creatine has the stronger evidence grade.

grade B moderate certainty

Meta-analysis of 16 RCTs (n≈492 adults): improved memory, attention, and processing speed; no significant effect on overall or executive function.

5 g/day

grade C low certainty

early, small studies suggest a modest cognitive effect

~1 g/day, adults

sources: PMID:39070254 · PMID:00000010