Caffeine vs Creatine

for energy / fatigue

Stronger evidence: Caffeine

Stronger effect: Caffeine

Safety: Caffeine carries a minor interaction; Creatine has none recorded.

For energy / fatigue, Caffeine has the stronger evidence grade.

grade B moderate certainty

reduces perceived fatigue; tolerance develops with regular use

40–200 mg

grade C low certainty

may reduce mental fatigue, especially under sleep deprivation or stress

3–5 g/day, adults

sources: PMID:00000021 · PMID:20000106