Caffeine vs CoQ10

for energy / fatigue

Stronger evidence: Caffeine

Stronger effect: Caffeine

Safety: Caffeine carries a minor interaction; CoQ10 has none recorded.

For energy / fatigue, Caffeine has the stronger evidence grade.

grade B moderate certainty

reduces perceived fatigue; tolerance develops with regular use

40–200 mg

grade C low certainty

limited evidence for general fatigue; clearer in specific conditions (e.g., statin myalgia, mitochondrial disorders)

100–200 mg/day, adults

sources: PMID:00000021 · PMID:10000009