Omega-3
declining omega-3 — attention cooling after large mixed/null trials
⚠ Safety in context
- seriouswith Warfarin: High-dose omega-3 with warfarin may increase bleeding risk.
Evidence by outcome
heart healthgrade Bmoderate certainty— modest cardiovascular benefit; large recent trials were mixed
inflammationgrade Bmoderate certainty— lowers circulating inflammatory markers (CRP, IL-6) dose-dependently
joint healthgrade Bmoderate certainty— reduces joint tenderness / morning stiffness in rheumatoid arthritis
moodgrade Cmoderate certainty— small benefit for depressive symptoms, clearest with higher-EPA formulations
cognitionnot well studiedvery-low certainty— not adequately studied for cognition in healthy adults
People say · Evidence shows
“Fish oil prevents heart attacks”
aheadlargemarketing claim
What changed
- B → B (2026-03-20) — A large cardiovascular outcomes trial missed its primary endpoint; state softened to mixed.
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More
sources: PMID:00000007 · PMID:20000103 · PMID:41886199 · PMID:20000102