Lion's Mane: what the evidence actually shows

emerging lion's mane — early hype, thin evidence

Reviewer and governance status are shown on each atomic claim below.

What it is

Lion's Mane is tracked as a health intervention in this evidence graph. Also known as: Hericium erinaceus, hericium, erinaceus.

Studied forms and doses

No form-specific catalog record is available. This does not mean all forms are equivalent.

cognition: ~1 g/day; form not reported.
mood: not standardized; form not reported.

Mechanisms

Mechanistic plausibility is context, not proof that a clinical outcome improves.

No structured mechanism is recorded.

⚠ Safety in context

No interaction record is modeled for this intervention. This is an unknown coverage state, not evidence that no interaction exists.

Products and verification

No product label snapshot is mapped in this released catalog. Ingredient evidence does not establish any bottle’s identity, potency, purity, availability, or value.

Evidence by outcome

cognitiongrade Clow certainty— early, small studies suggest a modest cognitive effect

moodgrade Dvery-low certainty— Review: Hericium erinaceus (lion's mane) has been reported to have mood and anxiety benefits in small studies, but the clinical evidence is very preliminary and not from large, confirmatory trials.

People say · Evidence shows

“Lion's mane regrows brain cells”

aheadlargemechanistic speculation

What it probably doesn't do

Lion's Mane for mood — Grade D, Review: Hericium erinaceus (lion's mane) has been reported to have mood and anxiety benefits in small studies, but the clinical evidence is very preliminary and not from large, confirmatory trials..

Grade history

2026-07-16C → CCorrection by Claude (gold-standard provenance sweep): live Postgres source drift replaced with the verified seed source set [pmid:18844328] details →

Re-review cadence: every 6 months (Grade C+) · next scheduled by 2027-01-16 · methodology v1.

By outcome — the money pages

Compare

Is Lion's Mane hype?

sources: PMID:18844328 · PMID:40959699

Cite this page

Citation is encouraged. The proposed reuse license is CC-BY-4.0; status: pending-governance-ratification.

Plain-text citation

Substrate. Lion's Mane: what the evidence actually shows. https://evidencebased.info/interventions/lions-mane. Updated 2026-07-16.

BibTeX

@misc{substrate_terventionslionsmane,
  author = {Substrate editorial},
  title  = {Lion's Mane: what the evidence actually shows},
  year   = {2026},
  url    = {https://evidencebased.info/interventions/lions-mane},
  note   = {evidencebased.info}
}