Creatine for cognition: C → B
New RCTs on cognitive performance (notably under sleep deprivation) strengthened the grade.
What triggered this change
The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.. Read: Substrate breakdown · PubMed.
What we said before vs now
Before
Grade C
After
Grade B
Meta-analysis of 16 RCTs (n≈492 adults): improved memory, attention, and processing speed; no significant effect on overall or executive function.
What this does not change
- Interaction profile for Creatine — unchanged unless there is a separate severity change.
- Dose guidance — unchanged unless the new evidence altered the studied dose range.
- Safety recommendations — unchanged unless a safety event is recorded separately.
Reviewer & methodology
Reviewed and signed by Substrate editorial (Independent research collective) on . Methodology v1.
See also
Cite this page
Reuse under CC-BY 4.0 with attribution to evidencebased.info.
Plain-text citation
Substrate. Creatine for cognition: C → B. https://evidencebased.info/changes/2026-05-02-creatine-cognition-c-to-b. Updated 2026-05-02.
BibTeX
@misc{substrate_reatinecognitionctob,
author = {Substrate editorial},
title = {Creatine for cognition: C → B},
year = {2026},
url = {https://evidencebased.info/changes/2026-05-02-creatine-cognition-c-to-b},
note = {evidencebased.info}
}