Zinc vs Omega-3
for mood
Stronger evidence: tie
Stronger effect: Omega-3
Safety: Omega-3 carries a serious interaction; Zinc has none recorded.
For mood, the two are evidence-matched; the difference is in effect and safety.
Zinc
grade C low certainty
may augment antidepressant response; deficiency-correction likely matters
25 mg/day, adults
Omega-3
grade C moderate certainty
small benefit for depressive symptoms, clearest with higher-EPA formulations
1–2 g EPA, adults with depression
sources: PMID:42197650 · PMID:20000102