Zinc vs St. John's Wort
for mood
Stronger evidence: St. John's Wort
Stronger effect: St. John's Wort
Safety: St. John's Wort carries a contraindicated interaction; Zinc has none recorded.
For mood, St. John's Wort has the stronger evidence grade.
Zinc
grade C low certainty
may augment antidepressant response; deficiency-correction likely matters
25 mg/day, adults
St. John's Wort
grade B moderate certainty
effective for mild-to-moderate depression in trials
300 mg ×3/day, adults, mild-to-moderate depression
sources: PMID:42197650 · PMID:00000009