Zinc vs Magnesium

for mood

Stronger evidence: Zinc

Stronger effect: Zinc

Safety: Magnesium carries a minor interaction; Zinc has none recorded.

For mood, Zinc has the stronger evidence grade.

grade C low certainty

may augment antidepressant response; deficiency-correction likely matters

25 mg/day, adults

studied, no effect moderate certainty

Not recommended for unipolar depression

sources: PMID:42197650 · PMID:35311615