Turmeric vs St. John's Wort
for mood
Stronger evidence: St. John's Wort
Stronger effect: St. John's Wort
Safety: St. John's Wort has the more serious interaction profile (moderate vs contraindicated).
For mood, St. John's Wort has the stronger evidence grade.
Turmeric
grade C low certainty
curcumin may reduce depressive symptoms as an adjunct; bioavailability-limited
500–1000 mg curcumin/day, adults with depression
St. John's Wort
grade B moderate certainty
effective for mild-to-moderate depression in trials
300 mg ×3/day, adults, mild-to-moderate depression
sources: PMID:42186284 · PMID:00000009