Probiotics vs Zinc
for mood
Stronger evidence: tie
Stronger effect: tie
Safety: No notable interactions recorded for either.
For mood, the two are evidence-matched; the difference is in effect and safety.
Probiotics
grade C low certainty
small effects on mood/anxiety in some "psychobiotic" trials; strain-specific, heterogeneous
strain-dependent, adults
Zinc
grade C low certainty
may augment antidepressant response; deficiency-correction likely matters
25 mg/day, adults
sources: PMID:42221774 · PMID:42197650