Omega-3 vs Glucosamine
for joint health
Stronger evidence: Omega-3
Stronger effect: Omega-3
Safety: Omega-3 carries a serious interaction; Glucosamine has none recorded.
For joint health, Omega-3 has the stronger evidence grade.
Omega-3
grade B moderate certainty
reduces joint tenderness / morning stiffness in rheumatoid arthritis
2–3 g EPA+DHA/day, adults with rheumatoid arthritis
Glucosamine
grade C low certainty
small and inconsistent osteoarthritis benefit; large independent trials disappointed
sources: PMID:41886199 · PMID:00000033