Magnesium vs Folate

for mood

Stronger evidence: tie

Stronger effect: tie

Safety: Magnesium carries a minor interaction; Folate has none recorded.

For mood, the two are evidence-matched; the difference is in effect and safety.

Magnesium

studied, no effect moderate certainty

Not recommended for unipolar depression

Folate

studied, no effect moderate certainty

Folic acid not recommended for unipolar depression

sources: PMID:35311615 · PMID:35311615