Myo-Inositol vs Berberine

for blood sugar

Stronger evidence: tie

Stronger effect: tie

Safety: Berberine carries a moderate interaction; Myo-Inositol has none recorded.

For blood sugar, the two are evidence-matched; the difference is in effect and safety.

grade B moderate certainty

improves insulin sensitivity and ovulatory function in PCOS in multiple RCTs

2–4 g/day myo-inositol, women with PCOS / insulin resistance

grade B moderate certainty

lowers fasting glucose and HbA1c; GI side effects common

500 mg ×3/day, adults with elevated glucose

sources: PMID:10000006 · PMID:00000030