Folate vs Saffron

for mood

Stronger evidence: Saffron

Stronger effect: Saffron

Safety: No notable interactions recorded for either.

For mood, Saffron has the stronger evidence grade.

studied, no effect moderate certainty

Folic acid not recommended for unipolar depression

grade B moderate certainty

multiple RCTs show benefit for mild-to-moderate depressive symptoms, comparable to low-dose SSRIs in small trials

30 mg/day, adults with mild-moderate depression

sources: PMID:35311615 · PMID:10000003