Creatine vs Omega-3

for mood

Stronger evidence: tie

Stronger effect: Omega-3

Safety: Omega-3 carries a serious interaction; Creatine has none recorded.

For mood, the two are evidence-matched; the difference is in effect and safety.

grade C low certainty

emerging evidence as an adjunct for depressive symptoms; trials small

3–5 g/day, adults with depression

grade C moderate certainty

small benefit for depressive symptoms, clearest with higher-EPA formulations

1–2 g EPA, adults with depression

sources: PMID:42180567 · PMID:20000102