5-HTP vs Vitamin D

for mood

Stronger evidence: tie

Stronger effect: Vitamin D

Safety: 5-HTP has the more serious interaction profile (serious vs minor).

For mood, the two are evidence-matched; the difference is in effect and safety.

grade C low certainty

preliminary antidepressant signal; small, lower-quality studies

grade C low certainty

small mood benefit, mostly in people who are deficient

sources: PMID:00000035 · PMID:00000005