5-HTP vs Magnesium

for sleep

Stronger evidence: Magnesium

Stronger effect: Magnesium

Safety: 5-HTP has the more serious interaction profile (serious vs minor).

For sleep, Magnesium has the stronger evidence grade.

grade C low certainty

limited evidence for sleep; serotonergic, so caution with antidepressants

grade B moderate certainty

modest improvement in sleep

200–400 mg, glycinate, adults

sources: PMID:00000036 · PMID:00000001