Soy Isoflavones vs Black Cohosh

for menopausal symptoms

Stronger evidence: Soy Isoflavones

Stronger effect: Soy Isoflavones

Safety: No notable interactions recorded for either.

For menopausal symptoms, Soy Isoflavones has the stronger evidence grade.

grade B moderate certainty

modest reduction in hot-flash frequency/severity; effect builds over weeks

40–80 mg isoflavones/day, menopausal women

grade C low certainty

inconsistent evidence for hot-flash relief; some trials positive, larger ones null

40 mg/day, peri/post-menopausal women

sources: PMID:10000005 · PMID:10000004