Saffron vs Valerian

for sleep

Stronger evidence: tie

Stronger effect: tie

Safety: No notable interactions recorded for either.

For sleep, the two are evidence-matched; the difference is in effect and safety.

Saffron

grade C low certainty

small RCTs suggest improved sleep quality

30 mg/day, adults

Valerian

grade C low certainty

small, inconsistent improvements in subjective sleep quality; trials are low-quality

300–600 mg, adults with insomnia
sources: PMID:41901246 · PMID:10000001