Rhodiola vs St. John's Wort

for mood

Stronger evidence: St. John's Wort

Stronger effect: St. John's Wort

Safety: St. John's Wort has the more serious interaction profile (uncertain vs contraindicated).

For mood, St. John's Wort has the stronger evidence grade.

studied, no effect moderate certainty

Not recommended for mood disorders

grade B moderate certainty

effective for mild-to-moderate depression in trials

300 mg ×3/day, adults, mild-to-moderate depression

sources: PMID:35311615 · PMID:00000009