Probiotics vs St. John's Wort
for mood
Stronger evidence: St. John's Wort
Stronger effect: St. John's Wort
Safety: St. John's Wort carries a contraindicated interaction; Probiotics has none recorded.
For mood, St. John's Wort has the stronger evidence grade.
Probiotics
grade C low certainty
small effects on mood/anxiety in some "psychobiotic" trials; strain-specific, heterogeneous
strain-dependent, adults
St. John's Wort
grade B moderate certainty
effective for mild-to-moderate depression in trials
300 mg ×3/day, adults, mild-to-moderate depression
sources: PMID:42221774 · PMID:00000009