Probiotics vs Saffron
for mood
Stronger evidence: Saffron
Stronger effect: Saffron
Safety: No notable interactions recorded for either.
For mood, Saffron has the stronger evidence grade.
Probiotics
grade C low certainty
small effects on mood/anxiety in some "psychobiotic" trials; strain-specific, heterogeneous
strain-dependent, adults
Saffron
grade B moderate certainty
multiple RCTs show benefit for mild-to-moderate depressive symptoms, comparable to low-dose SSRIs in small trials
30 mg/day, adults with mild-moderate depression
sources: PMID:42221774 · PMID:10000003